Tag Archives: Hemodiafiltration Machine

Point of Entry Filtration – Facts You Need to Know

People have been shifting to point of entry filtration these days. It is quite convenient as you do not have to install a filter and various points. You will get filtered water from every faucet in your home because of point of entry filtration.


What is the Point of Entry Filtration?


Point of entry filtration frameworks are placed in the main water line where water enters the household This entry point is, as a rule, is found within the garage, and the frameworks are generally set before water radiators to convey purified cold and hot water to each tap within the home. They convey the treated water to all sinks, showers, baths, dishwashers, fridges, toilets and washing machines– fundamentally covering the full house.




Here are some of the benefits of point of entry filtration.


One Filter


Point of entry filtration is a very good investment both in regards to your health and home because it includes the filtration of the dirty water before it can reach any of the taps installed in your home. The point of entry filtration technique eliminates the requirement of any other individual filters at every tap in your house.


Protection Against Contamination


If you have an issue with your water having rust and iron the point of entry filtration will help in reducing the contaminants. Iron and rust are very harmful as they leave behind residue in your drains and toilets.


Easy Monitoring


Point of entry filtration has a very good feature of monitoring the water and controlling it from a centralized problem. This serves as a very convenient option as you can easily know what the problem is and easily replace filters if an issue arises. This solves your problem of maintaining a number of filters.


Considering Point of Filtration to Avoid Chlorination?


One of the foremost common reasons for installing point of entry filtration treatment is so prevalent is the negative discernment of centralized treatment including chlorination. In spite of the reality that the chlorination of water is exceptionally effective in slaughtering infections and is one of the most noteworthy public wellbeing propels in human history, it encompasses an exceptionally negative recognition due to the difference in taste and scent, and the concerns of its toxicity.


Capacity To treat water


Point of entry filtration offers a  large capacity filtration and treats around a few thousand gallons every day. They are ordinarily bigger in size with small mountable units, varying from 20” H x 4.5D to taller unsupported mineral tanks up to 65” or more in stature. These flexible units can utilize an assortment of diverse filter media beds and cartridges to essentially expel any sort of water defilement. The greater volume and capacity of the frameworks make them very tough and maintenance-free with a few bigger units and needs replacing after each 5-7 years.




This is quite an effective method for purifying water but if you combine it with the Point of use filtration you will get better results and can obtain drinking water too. This framework is quite hasslefree and is the right step towards pure water.

Nephros Inc. Also Offers Following Services :

Ultrafilter Dialysis

Infection control water


Hemodiafiltration Machine


What are Endotoxin Filters?

Endotoxins are very small molecules of lipopolysaccharide that exist on the cell wall of a bacteria called Gram-negative. Bacterial endotoxins combine with different cellular material and create an endotoxin complex. Before you know about what are endotoxin filters, you should understand why are endotoxins harmful and how they can be removed. This article will give you all the relevant information. So, read along and discover the answers to all your queries related to endotoxin filters.

Why are endotoxins harmful?

Endotoxins are pyrogenic. They pose a serious threat to the patients who are administered intramuscular and intravenous preparations. Endotoxins might contaminate different biologic products either through water or via raw materials like media, equipment, additives, sera, excipients, container closure, and expression systems, etc.

What are the different methods of removing endotoxin?

There are many methods to remove endotoxins. Some of them are ultrafiltration, chromatography, electrophoresis, etc. They can also be removed by using appropriate detergents.

How do endotoxin filters help the process of ultrafiltration?

The molecules of endotoxin build up micelles in aqueous solutions. They can be removed from such solutions through the process of filtration. This is where endotoxin filters are used. During ultrafiltration, the endotoxins are eliminated by using a super-fine filter. Such a filter blocks molecules even greater than 10, 000 Daltons. This process works very well along with a filter of 0.1 μm.

The process of ultrafiltration might be effective in the case of water solutions. It, however, has little effect on the removal of endotoxins in protein solutions. Though ultrafiltration does not involve much of an expense, it cannot be treated as a reliable method of removing endotoxins.

How does endotoxin filters remove endotoxins?

Endotoxin filters are chemically modified. They carry a positive charge and apply them to eliminate endotoxins through charge interactions. The charge character of such filters is titrated potentiometrically. One can achieve an optimized filter performance by following the laboratory instructions framed for endotoxins removal.

How to find the best endotoxin filters?

The most effective endotoxin filters would be positively charged. They would also come equipped with a hydrophilic membrane which will remove the endotoxins completely from different solutions. Endotoxin filters that have amine charged, cross-linked quaternized surfaces are highly recommended. This is important for the removal of endotoxins from water, process feedstreams, and buffers, even under selected conditions.

Apart from this, choose an endotoxin filter that filters out even the smallest particulates. It should meet either the ISO 11663 or AAMI or ANSI standards. It should also come with a clearance of FDA 510 (k). While some filters are designed for minimal flow disruptions, others are perfect in case of low flow situations. Look for a filter that is sturdy, durable, and has a life span of around 12 months.

Endotoxins are harmful components. Therefore, the earlier they are eliminated from the solutions, the better the results will be. Now that you know a lot about endotoxin and its filters, you know what to look for when buying a properly functional filter.


Nephros Inc. Also Offers Following Services :

Lead Filters

Hemodiafiltration Machine

Contact US:

Nephros Inc.
Address:380 Lackawanna Pl,  South Orange, NJ
Phone: (201) 343-5202