Category Archives: Dialysis Filter

What are Endotoxin Filters?

Endotoxins are very small molecules of lipopolysaccharide that exist on the cell wall of a bacteria called Gram-negative. Bacterial endotoxins combine with different cellular material and create an endotoxin complex. Before you know about what are endotoxin filters, you should understand why are endotoxins harmful and how they can be removed. This article will give you all the relevant information. So, read along and discover the answers to all your queries related to endotoxin filters.

Why are endotoxins harmful?

Endotoxins are pyrogenic. They pose a serious threat to the patients who are administered intramuscular and intravenous preparations. Endotoxins might contaminate different biologic products either through water or via raw materials like media, equipment, additives, sera, excipients, container closure, and expression systems, etc.

What are the different methods of removing endotoxin?

There are many methods to remove endotoxins. Some of them are ultrafiltration, chromatography, electrophoresis, etc. They can also be removed by using appropriate detergents.

How do endotoxin filters help the process of ultrafiltration?

The molecules of endotoxin build up micelles in aqueous solutions. They can be removed from such solutions through the process of filtration. This is where endotoxin filters are used. During ultrafiltration, the endotoxins are eliminated by using a super-fine filter. Such a filter blocks molecules even greater than 10, 000 Daltons. This process works very well along with a filter of 0.1 μm.

The process of ultrafiltration might be effective in the case of water solutions. It, however, has little effect on the removal of endotoxins in protein solutions. Though ultrafiltration does not involve much of an expense, it cannot be treated as a reliable method of removing endotoxins.

How does endotoxin filters remove endotoxins?

Endotoxin filters are chemically modified. They carry a positive charge and apply them to eliminate endotoxins through charge interactions. The charge character of such filters is titrated potentiometrically. One can achieve an optimized filter performance by following the laboratory instructions framed for endotoxins removal.

How to find the best endotoxin filters?

The most effective endotoxin filters would be positively charged. They would also come equipped with a hydrophilic membrane which will remove the endotoxins completely from different solutions. Endotoxin filters that have amine charged, cross-linked quaternized surfaces are highly recommended. This is important for the removal of endotoxins from water, process feedstreams, and buffers, even under selected conditions.

Apart from this, choose an endotoxin filter that filters out even the smallest particulates. It should meet either the ISO 11663 or AAMI or ANSI standards. It should also come with a clearance of FDA 510 (k). While some filters are designed for minimal flow disruptions, others are perfect in case of low flow situations. Look for a filter that is sturdy, durable, and has a life span of around 12 months.

Endotoxins are harmful components. Therefore, the earlier they are eliminated from the solutions, the better the results will be. Now that you know a lot about endotoxin and its filters, you know what to look for when buying a properly functional filter.

 

Nephros Inc. Also Offers Following Services :

Lead Filters

Hemodiafiltration Machine

Contact US:

Nephros Inc.
Address:380 Lackawanna Pl,  South Orange, NJ
Phone: (201) 343-5202

How To Choose The Best Water Filter

There are many contaminating agents like pharmaceutical residues, PFCs, heavy metals and also pesticides that are found in all water supplies around the globe. They cannot be totally eliminated or wished away. Hence, there is a need to find out ways and means by which we can protect us and our families from the negative health impact of these contaminating the water supplies that we drink and use for other purposes. As the water levels and water bodies and water tables continue to move down, the risk of contamination continues to be there. Hence, the best way to address this problem is to choose a good water filter in general and lead filter in general. This is because lead is one of the most dangerous contaminants in water and poisoning associated with lead happens gradually over a period of time. Before choosing the right water filter for your home, there are a few things that must be considered.

Know The Source Of Water

Before choosing the right lead water filter, there is a need to find out the source of water. There are simple ways by which this can be done. The first and foremost step is to go by the certificates that are available based on tests conducted by the municipal authorities. These tests will prove the level of contamination and the various contaminating agent that is involved. Based on this, you will be able to choose the right water filter that can handle such contaminants.

Reports From Water Utilities

There are many water suppliers and utilities who often issue yearly water quality reports. This will be able to ensure that you are in a position to choose the right water filter keeping in mind the reports that emanate from such water utilities. Of course, there could be chances of new contaminants being picked up as the water reaches your home. Hence, there is a need to also conduct the right home water tests before choosing the right water filter.

Different Types Of Water Filter

Pitcher filters are popular but we must understand that these filters can remove a few contaminants including chlorine. Further, the water generally sits in a plastic container for a long period of time. This could also lead to more harmful chemicals being picked up from the pitcher itself. At best pitcher filters could be useful in improving the taste and odor of the water rather than offering anything more substantial.

Faucet-Mount Filter

There are many faucet-mount filters that have the capacity of removing a decent amount of contaminants. Before buying such filters it would always be better to read the fine print and be sure about the contaminants that they are capable of removing. These filters are no doubt inexpensive and can easily be replaced without the need for special skills. The initial cost in some cases could be more but the benefits of such faucet mount filters over the long term can be quite interesting.

Countertop Water Filter

Countertop filters are considered good because they do not take up too much of space under your sink. Hence it can be fixed on to the faucets or it could be freestanding. It doesn’t require the need for refilling the water again and again because the filter is connected to the main water source.

Contact US:

Nephros Inc.
Address:380 Lackawanna Pl,  South Orange, NJ
Phone: (201) 343-5202